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21 CFR 207.69 compliance

Avoid FDA drug detention.
Secure your US agent in 12 minutes.

21 CFR 207.69 demands a physical U.S. presence for all foreign drug manufacturers. We guarantee instant CDER acceptance and full liability protection for a flat $399/year. Stop paying $1,300+ to legacy consultants.

Appoint Assurentry ($399/yr)

No hidden fees • Cancel anytime • 100% FDA acceptance

ENFORCEMENT ALERT: CDER SUSPENDS FACILITY FOR UNRESPONSIVE AGENT
IMPORT REFUSAL (66-40): U.S. AGENT CANNOT BE CONTACTED
WARNING LETTER: FAILURE TO PAY GDUFA RE-INSPECTION FEES
REGULATORY UPDATE: FDA ESG INTEGRATION REQUIRED FOR SPL
URGENT: 21 CFR 207.69 MANDATES PHYSICAL U.S. PRESENCE
ENFORCEMENT ALERT: CDER SUSPENDS FACILITY FOR UNRESPONSIVE AGENT
IMPORT REFUSAL (66-40): U.S. AGENT CANNOT BE CONTACTED
WARNING LETTER: FAILURE TO PAY GDUFA RE-INSPECTION FEES
REGULATORY UPDATE: FDA ESG INTEGRATION REQUIRED FOR SPL
URGENT: 21 CFR 207.69 MANDATES PHYSICAL U.S. PRESENCE
ENFORCEMENT ALERT: CDER SUSPENDS FACILITY FOR UNRESPONSIVE AGENT
IMPORT REFUSAL (66-40): U.S. AGENT CANNOT BE CONTACTED
WARNING LETTER: FAILURE TO PAY GDUFA RE-INSPECTION FEES
REGULATORY UPDATE: FDA ESG INTEGRATION REQUIRED FOR SPL
URGENT: 21 CFR 207.69 MANDATES PHYSICAL U.S. PRESENCE
The gatekeeper threat

Import Alert 66-40 is triggered instantly.

If your drug establishment registration lapses, or if your U.S. Agent fails to respond to an FDA inquiry, your facility is automatically placed on FDA Import Alert 66-40. Every shipment you send to the U.S. will be halted at the port. Demurrage fees start immediately, ruining distribution contracts.

Protect your shipments

Instant CBP unblocking • Immediate digital certificate

CBP.GOV // ACE Terminal
[SYSTEM] INITIATING CBP CLEARANCE...
[SYSTEM] CHECKING PRIOR NOTICE #49281...
[DATA] FACILITY FEI = 30045291
[WARN] PINGING FDA CDER DATABASE...
[ERROR] U.S. AGENT DESIGNATION = NULL
[FATAL] DRUG ESTABLISHMENT REG = INACTIVE
[ACTION] TRIGGER IMPORT ALERT 66-40
[ACTION] INITIATING DWPE PROTOCOL
[SYSTEM] SHIPMENT HALTED AT PORT OF ENTRY
[SYSTEM] INITIATING CBP CLEARANCE...
[SYSTEM] CHECKING PRIOR NOTICE #49281...
[DATA] FACILITY FEI = 30045291
[WARN] PINGING FDA CDER DATABASE...
[ERROR] U.S. AGENT DESIGNATION = NULL
[FATAL] DRUG ESTABLISHMENT REG = INACTIVE
[ACTION] TRIGGER IMPORT ALERT 66-40
[ACTION] INITIATING DWPE PROTOCOL
[SYSTEM] SHIPMENT HALTED AT PORT OF ENTRY
[SYSTEM] INITIATING CBP CLEARANCE...
[SYSTEM] CHECKING PRIOR NOTICE #49281...
[DATA] FACILITY FEI = 30045291
[WARN] PINGING FDA CDER DATABASE...
[ERROR] U.S. AGENT DESIGNATION = NULL
[FATAL] DRUG ESTABLISHMENT REG = INACTIVE
[ACTION] TRIGGER IMPORT ALERT 66-40
[ACTION] INITIATING DWPE PROTOCOL
[SYSTEM] SHIPMENT HALTED AT PORT OF ENTRY

Entry Refused

HOLD: IMPORT ALERT 66-40

REASON CODE: NO U.S. AGENT
ESTABLISHMENT STATUS: UNREGISTERED
Demurrage Accruing
3,500
/ DAY
Radical transparency

The hidden fee trap.

Legacy regulatory firms lure you in with a $449 base fee, then charge $349 for Labeler Codes, $199 for NDCs, and $399 for DUNS assistance. You end up paying $1,396+. We believe in one flat rate: $399/year.

Compliance Task
Apex Standard
Assurentry
Legacy firms
Annual representation fee
$399 Flat
$495 - $695 Base
Annual registration renewal
Included Free
$250 - $495 Extra
SPL generation & listing
Included Free
$345+ Per Listing
DUNS validation & support
Included Free
$300+ Extra
FDA Re-inspection liability
Assurentry Shield
You pay $10k+ fees
Est. Total Cost / Yr
$399
~$1,800+
FDA 21 CFR 207.69

"Each foreign establishment must designate one person who resides or maintains a place of business in the United States to be its U.S. agent... The use of a post office box does not meet this requirement."

P.O. Box / Virtual

REG CANCELLED

Assurentry HQ

PHYSICAL PRESENCE
Physical presence mandate

The physical presence mandate.

21 CFR 207.69 dictates you cannot use a virtual office, a P.O. Box, or an answering machine. The law is absolute. We provide a guaranteed legal foothold in the United States.

  • Geographic Reality: Must reside in the US.
  • 24/7 Availability: FDA emergency contact.
  • Legal Proxy: Representations are legally binding.
Secure your legal US address

100% compliant with 21 CFR 207.69

Financial protection

The FDA re-inspection liability trap.

Under GDUFA and FSMA, the U.S. Agent is financially liable for FDA re-inspection costs (often exceeding $10,000). Competitors refuse to act as agents or charge massive retainers. Assurentry absorbs this risk.

FDA Re-inspection Bill

Due immediately
BILL TO:U.S. AGENT OF RECORD
AUTHORITY:GDUFA / FSMA
AMOUNT DUE:12,450.00

The FDA bills the U.S. Agent directly for all facility re-inspection costs. If the agent does not pay, your facility registration is suspended.

Assurentry Shield

No extortion retainers

Because of this massive financial liability, legacy competitors force you to sign predatory contracts or deposit $10,000+ into an escrow account just to act as your agent.

We charge a flat $399.

Our corporate liability insurance absorbs the risk, meaning you keep your capital while maintaining perfect FDA compliance.

Get the Assurentry liability shield

Included free with your $399 flat fee

FDA CDER correspondence

Translating CDER legalese.

When the FDA sends a Form 483 or Warning Letter, it is written in dense regulatory code. Misinterpreting it can lead to facility suspension. We translate the risk into an actionable CAPA plan.

Raw FDA Form 483
CDER_NOTICE

During an inspection of your firm located at the above address on [DATE], an investigator from the United States Food and Drug Administration (FDA) determined that your firm manufactures drug products.

We found significant violations of current good manufacturing practice (CGMP) regulations for finished pharmaceuticals, Title 21, Code of Federal Regulations, Parts 210 and 211 (21 CFR parts 210 and 211).

Your firm failed to establish and follow appropriate written procedures that are designed to prevent microbiological contamination of drug products purporting to be sterile, and that include validation of all aseptic and sterilization processes (21 CFR 211.113(b)).

Failure to promptly correct these violations may result in legal action without further notice, including, without limitation, seizure and injunction.

Action Plan
CDER Warning: CGMP Violation
FDA inspector flagged a failure in aseptic validation during the last facility audit.
Draft formal CAPA response to CDER within 15 days.
Review and update sterilization SOPs.
Upload remediation evidence via ESG.
Electronic submissions

Flawless SPL & ESG integration.

Unlike food facility registration, drug listings must be submitted to the FDA via the Electronic Submissions Gateway (ESG) using raw SPL XML files. Our U.S. Agent details perfectly match your SPL payloads.

Electronic Submissions

FDA ESG & SPL Integration.

Unlike food registrations which use web portals, drug establishments and product listings must be submitted to the FDA via the Electronic Submissions Gateway (ESG) using raw SPL XML files.

Seamless SPL Connection

We ensure your U.S. Agent details perfectly match your SPL XML payloads, preventing ESG rejection errors.

SPL PAYLOAD
.XML
<assignedEntity>
<assignedOrganization>
<name>Assurentry</name>
<id root="DUNS" extension="..."/>
</assignedOrganization>
</assignedEntity>
FDA ESG
Submissions Gateway
Data integrity

Mastering the FEI disconnect.

The exact spelling and address format in the FDA database must cryptographically match the Dun & Bradstreet database to generate your FDA Establishment Identifier (FEI). If it doesn't, your registration fails.

Dun & Bradstreet

UFI / DUNS:12-345-6789
LEGAL NAME:Pharma Corp LLC
ADDRESS:123 Industrial Way
CryptographicHandshake
0x9A4F... MATCH

FDA CDER DB

FEI NUMBER: 30045291
LEGAL NAME: MATCH
REG STATUS:ACTIVE
Audit readiness

The Notice of Inspection (NOI) interceptor.

When the FDA decides to inspect your foreign drug facility, they call your U.S. Agent first to schedule it. A missed call flags you as non-cooperative. We intercept, negotiate dates, and prep your QA team.

CDER Action
Notice of Inspection (NOI)
FDA calls
U.S. Agent

FDA"We are scheduling a CGMP inspection of your client's facility in 5 days. Confirm receipt."

Without an agent answering, the FDA flags the facility for non-cooperation immediately, putting all U.S. distribution at risk.

Assurentry Defense
Immediate
Triage
Negotiate optimal inspection date.
Alert facility QA team & prep records.
CDER compliance

The annual renewal trap.

Unlike food facilities (biennial), drug establishment registrations must be affirmatively renewed every single year between October 1 and December 31. Assurentry automatically files your renewal paperwork via SPL for free. You will never wake up on January 1st to a cancelled registration.

Automate your annual renewals

Included free with your subscription

Action Required
FDA CDER Mandate

Annual Renewal

Unlike food facilities, drugs require renewal every single year.

Jan 1 - Sep 30
Business as usual

Auto-Renewal

Our system automatically initiates the annual renewal via the FDA ESG, verifying DUNS and FEI matches free of charge.

October 1
Window Opens
Failure to renew = cancellation on Jan 1st.
December 31
Deadline
Global coverage

FDA emergencies wait for no one.

The FDA operates on EST. If an adverse event or recall notice is sent at 4:00 PM EST, it might be 4:00 AM in your country. We provide 24/7/365 coverage for over 160+ countries.

Global Pharmacovigilance

CDER emergencies wait for no one.

The FDA operates on U.S. Eastern Standard Time (EST). If an emergency communication is sent at 4:00 PM EST regarding an adverse event or recall, it might be 4:00 AM in your country. The FDA expects the U.S. Agent to answer immediately.

24/7/365 Coverage

We support over 160+ countries. When the FDA calls, we answer on the first ring.

04:00
PM EST (FDA)
05:00
AM (Berlin)
Assurentry Answering
Compliance repository

The secure audit vault.

Every CDER interaction, establishment registration, and NDC labeler code is cryptographically stored and instantly accessible for your buyers or inspectors.

Regulatory Document Vault

Every CDER interaction, establishment registration, and NDC labeler code is cryptographically stored and instantly accessible.

Verified

U.S. Agent Designation Cert

0x8F9B2A...
PDF / SECUREToday
Archived

Establishment Registration

0x3C4D1E...
PDF / SECUREOct 2024
Active

NDC Labeler Code Record

0x7A2B9C...
PDF / SECUREToday
Search vault for "FDA Form 483 2023"
CTRL + K
Frequently asked questions

Radical transparency.

We answer the hard questions our competitors won't.

One flat fee. Complete peace of mind.

Stop paying hourly retainers for mandatory compliance.

Complete package

U.S. agent designation

The complete compliance representation package for pharma.

$399/ year
Secure your agent

Secure SSL checkout. No setup fees. Cancel anytime.

What's included:

  • Official 21 CFR 207.69 Designation
  • Liability Shield (Re-inspection fees)
  • Free Annual Renewal Filing
  • ESG & SPL Validation Support
  • Free DUNS Validation Support
  • Unlimited FDA Comm Handling
  • Digital Compliance Certificate

Certificate of Designation

U.S. AGENT FOR PHARMACEUTICALS

This certifies that
YOUR PHARMA CORP
has appointed
ASSURENTRY LLC
As their official U.S. Agent pursuant to 21 CFR 207.69
Date of Issue
Mar 3, 2026
Blockchain ID
0x4F92...B81A
21 CFR 207.69 Validated
100% FDA Acceptance Guarantee

Secure Your Supply Chain.

Don't let a clerical error stop your shipment at the border. Join 2,800+ food companies who trust Assurentry for automated compliance.

256-bit Encrypted
Instant PDF
4.9/5 Rating
Official US Agent